Italy‘s third-largest city, Naples is a bustling metropolis famed for it stately buildings, crowded streets, pizza – and notoriously bad traffic. However, this beautiful city is rich in centuries-old culture and customs. Naples is also your gateway to the Isle of Capri, the fabled Amalfi Coast and the ruins of Pompeii, buried in ash by the cataclysmic eruption of Mt. Vesuvius in 79 A.D. Naples boasts an ideal location, with both the ruins of Roman cities and the stunning Amalfi Coast in easy reach.

Messina has played a major role in European history since its founding as a Greek colony in the 8th century B.C. During the Roman Empire, the city was a major port and commercial center, during the Middle Ages, Messina was the major port of departure for Crusaders. History has also left its scars: a massive earthquake leveled much of the city in 1908 and the World War II campaign for Sicily devastated Messina. Yet Messina emerged from that devastation with some of its historic treasures intact, including the 12th-century Annunziata dei Catalani Church. Messina is also your gateway to the rugged beauty of southeast Sicily, from the seaside resort of Taormina to Mt. Etna. Between the fall of Rome and the 1861 unification of Italy, the Arabs, the Normans, the Germans, the Spanish and the French ruled Sicily.

Chania is a city on the northwest coast of the Greek island of Crete. It’s known for its 14th-century Venetian harbor, narrow streets and waterfront restaurants. At the harbor entrance is a 16th-century lighthouse with Venetian, Egyptian and Ottoman influences. Opposite, the Nautical Museum has model ships, naval objects and photographs.

Istanbul rises from the Bosphorus, a vision of minarets and domes sparkling in the light. The capital of vanished empires, Istanbul is a true crossroad, the only city on Earth to span two continents. This meeting place of Europe and Asia, of Christian and Muslim, is one of the great adventures a traveler encounters. Browse the stalls of the world‘s largest bazaar, explore ancient mosques and churches, and gaze at the stunning jewels in the Topkapi Palace. Istanbul has dominated the Straits of Bosphorus for 25 centuries. As Constantinople, capital of the Eastern Roman Empire, it was a metropolis of stunning splendor when the great cities of Europe were mere villages.

Thanks to its proximity to the mainland, Mykonos was one of the first Greek islands to become an international travel destination. During the late ‘60s and early ‘70s, Mykonos was famed as a haunt for the rich. The island‘s nightlife – then and now – was a glittering whirl of colored lights, music, and parties. But there‘s another side to Mykonos – the neighboring island of Delos. In classical mythology, Delos was the birthplace of Apollo and his twin sister Artemis. Travelers to Delos can stroll among the island‘s vast ruins, which include three temples consecrated to the Sun God and the famed Lions Walk. Mykonos town features hip boutiques, restaurants, jewelry stores, souvenirs, taverns and cafés. The island‘s famed windmills are found just south of the waterfront.

The past maintains a vibrant presence in the cradle of Western civilization. Atop the Acropolis, the serene Parthenon sails above the commotion of the modern city. The tragedies of Aeschylus, Sophocles, and Euripides were performed in the Theater of Dionysus at the foot of the Acropolis. On Pnyx Hill, citizens of a fledgling democracy gathered to cast their votes on Athens‘ destiny. Then there is the hustle and bustle of the modern city, a metropolis of 4.5 million that spreads out from the foot of Mt. Lycabettus and across the plain. Packed with busy shops and lively tavernas, modern Athens is a colorful counterpoint to classical Greece. Piraeus is the port city for Athens and has been Athens‘ port of entry for over two millennia.